|
KMID : 0882420100790010016
|
|
Korean Journal of Medicine
2010 Volume.79 No. 1 p.16 ~ p.22
|
|
|
The clinical characteristics of noncardiac chest pain and treatment response in non-erosive reflux disease (NERD)
|
|
Choi Tae-Hyuck
Lee Dong-Ho
Jeong You-Jeong
Lee Byoung-Hwan
Hwang Tae-Jun
Park Young-Soo
Kim Na-Young
|
|
|
Abstract
|
|
|
Background/Aims: Noncardiac chest pain (NCCP) is defined as recurring angina-like retrosternal chest pain of noncardiac origin. Gastroesophageal reflux disease (GERD) is by far the most common cause of NCCP. We evaluated the incidence of some esophageal abnormalities as a cause of NCCP and the treatment response to a proton pump inhibitor (PPI).
Methods: Forty seven NCCP cases were selected from 184 cases who underwent 24-hour ambulatory pH monitoring or esophageal manometry. Patients were excluded if they had a history of gastrointestinal surgery, pancreatobiliary disorder, coronary artery disease, valvular heart disease, depression or tuberculosis. In this study, all GERD patients had non-erosive reflux disease (NERD).
Results: Of the 47 NCCP cases, 30 (63.8%) were female and 17 (36.2%) were male. Only 7 (14.9%) cases had typical GERD symptoms such as acid regurgitation and heartburn. Of the 47 NCCP cases, 12 (25.5%) had GERD-related NCCP, and six (12.8%) had esophageal motility disorder. Of the 12 cases diagnosed as GERD- related NCCP, nine (75.0%) showed a satisfactory PPI response. The PPI was effective for GERD-related NCCP compared with non-GERD related NCCP (p =0.015).
Conclusions: About 40% of NERD patients with NCCP had an esophageal disorder including GERD and esophageal motility disorder. A PPI was effective for GERD-related NCCP.
|
|
|
KEYWORD
|
|
|
Noncardiac chest pain, Non-erosive reflux disease, Proton pump inhibitors
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|